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SARMS Reviewed and Explained

The words SARMS stands for Selective Androgen Modulator, they can either block, or stimulate, the same nuclear hormone receptors under different conditions. Consequently, if it can block or stimulate a receptor in a tissue selective manner, it may be able to mimic the beneficial effects in one tissue. And, at the same time, minimize the unwanted effects of the synthetic steroidal hormones in other tissues. Since SARMS are a class of androgens , they can bind to cellular androgen receptors. As a result, the androgen receptors will trigger a complex signal transduction pathway that will lead to a greater expression of specific genes.

SARMS VS. ANABOLIC STEROIDS

In fact, anabolic androgenic steroids (AAS) and prohormones also bind to the androgen receptors, resulting in muscle growth. However, SARMS possess full anabolic activity in muscle and bone. Yet they have a minimal effect on the prostate as opposed to AAS, which can be very harmful to this gland. As an additional advantage, they are orally available and require no injections. In spite of being oral compounds, SARMS are not methylated, so they are not liver toxic. Due to the fact that SARMS are very specific to the androgen receptors, they can be extremely useful for safe muscle building. All in all, they have an abundance of qualities. They are highly beneficial to bones, muscle tissues, and sexual function without the conversion of androgens into estrogens seen with steroids or prohormones. Hence, SARMS offer the benefits of anabolic steroids, but they do not cause the side effects commonly associated with AAS. This quality makes them extremely desirable and intriguing to any class of users.

HISTORY OF SARM

The development of steroidal SARMs started in the 1940's with modifications made to the testosterone molecule. Since then, pharmaceutical companies have been testing them for a variety of health benefits, which range from anti-obesity and bone health promotion, to fighting different diseases and counteracting muscle wasting.

WHERE DO SARMS COME FROM AND WHY WERE THEY DEVELOPED?

Steroids are generally prescribed by medical practitioners for two common reasons. The first, to treat muscle wasting diseases which usually take place with such conditions as cancer and osteoporosis. The other scenario takes place when steroids are prescribed for Hormonal or Testosterone Replacement Therapy (TRT). However, the main problem with steroids is that they often cause many unwanted effects. And they have pharmokinetic properties that are not desirable. Meanwhile, SARMS's ability to stimulate a receptor in a tissue selective manner allows them to mimic the beneficial effects of androgen activation in muscles. At the same time the side effects of natural steroidal hormones can be minimized. In simple terms, SARMS are able to selectively induce muscle growth, avoiding the unwanted side effects.

WHY ARE SARMS BENEFICIAL?

As mentioned above, SARMS have steroid like results without the many unwanted side effects that AAS can cause. Here are the side effects of Anabolic Steroids (none of which are present with SARMS use).

  • Potential stimulation of prostate cancer
  • Male pattern baldness
  • Acne
  • Body hair growth
  • Gynecomastia (male breast development)
  • High blood pressure
  • Liver toxicity
  • Cholesterol imbalance
  • Left Ventricular Hypertrophy (Heart growth)
  • Suppression of the natural testosterone production
  • Water retention
  • Bloating

Thus, SARMS are a much safer option to steroids because the selective stimulation of the androgen receptors only in bone and muscle tissue will prevent many, if not all, of the side effects listed above. Besides, they also have the advantages of oral dosing, which testosterone and some steroids do not have.

HOW SARMS APPLY TO BODYBUILDERS

SARMS can be used by bodybuilders, gym users, fitness enthusiasts, or athletes either in conjunction with, or as a replacement for, traditional anabolic steroids for the following purposes:

  • Lean muscle growth
  • Prevention of muscle loss during cutting/weight loss
  • Injury rehabilitation
  • PCT use after AAS cycles

UTILIZING SARMS

There are several possible ways to implement SARMS in you cycle, as they have a place and benefit in any situation. For example, they became popular as a "bridge" in-between anabolic steroid cycles. Using them in this manner allows the user to have a much easier time keeping and/or adding to gains made on previous cycles. This can be done without having to worry about the side effects and drastic suppression one would experience with AAS use.

SARMS CYCLES

SARMS can be cycled for any type of goal - cutting, recomposition or bulking. Over the years, SARMS have proven to be extremely versatile and have the capability to achieve any type of goal. Generally, these compounds have an area where they truly shine, but when ran in a stack, the synergy between them allows maximum results. For instance, Testolone (RAD-140) and Anabolicum (LGD-4033) are best used in a bulking type of cycle, while Ostabolic (MK-2866) is best suited for a recomposition. On the other hand, for a cutting cycle one should opt Cardarine (GW-501516) and Stenabolic (SR9009). At the same time, Nutrobal (MK677) will fit in any cycle, as it has the ability to cut fat and add great size at the same time. Hence, if chosen properly, SARMS can help you achieve any goal you desire. Usually, SARMS cycles tend to range from 12 to 16 weeks, depending upon the choice of the chemical. After the cycle completion, a mini post cycle therapy (mini pct) is all that is needed, as recovery from them is much easier than with anabolic steroids. A small protocol of clomid and Cardarine during 4 weeks is more than enough. Then, a small rest period of 2-3 weeks is necessary before beginning again. In fact, Cardarine (GW) and Stenabolic (SR) require no PCT at all if ran alone. This is another characteristic that makes these compounds an optimal choice over AAS and PH use.

PHASES OF SARMS USE

Sarms can be utilized in four different ways.

1. RECOMP

This is probably the most popular way to use SARMs. Anabolic steroids do not burn fat, and we know this as a fact. However, they do burn fat, so if you are looking to recomp and want to avoid shutting yourself down, they can be utilized perfectly in this situation, especially combined with proper diet and cardio. Moreover, they have a great ability to add lean muscle mass while you burn fat, which makes them great for recomp.

2. STRENGTH

SARMs can increase strength extremely rapidly because they bind to your androgen receptors so fast. The beauty part of this is that, unlike anabolic steroids, they can help heal joints, allowing you to go heavier without fearing injuries. This is very beneficial for those who always complain about nagging joint issues.

3. CUTTING

The secret to SARMís fat burning properties is their ability to decrease lipoprotein lapase enzyme, which will prevent fat from being added. Combine the PPAR GW to your SARMs stack, along with diet and cardio, and you can shred up very fast on it.

4. BULKING

Unfortunately, it is not the best way to utilize them, but if you do not want to deal with HPTA (hypothalamic pituitary testicular axis) suppression, then you can most certainly bulk on them combined with weight training and increased calorie intake.

HOW TO USE

SARMs come in liquid form, and it is not recommended to mix them in a cup and then drink or to hold under the tongue. The proper way to ingest is simply squirt into the mouth your desired dosage and swallow it, then chase down with some water or juice. Dosages are dependent on the specific SARM(s) you are using, hence, please read future articles for individual information.

SUMMARY

Although SARMS are considered to be in an earlier phase of development, the potential for these compounds is very high, which is made evident by the number of pharmaceutical firms currently developing different products. As a summary, we can say that they offer the following benefits:

  • Oral route of administration (no injections needed)
  • Similar effects to testosterone (libido, strength gains, fat loss, muscle growth, etc.)
  • No conversion to DHT (dihydrotestosterone- no problems with body hair growth, and hair loss on the head)
  • Without conversion to estrogen
  • None of the liver toxicity that is usually seen with methylated compounds, such as prohormones and oral steroids
  • No inhibition of your HPTA to the large extent of steroids (minimal reduction in LH or FSH)
  • Legal to buy and use for research
  • Undetectable (certain SARMS)
  • Even though a slight HPTA suppression may be present at higher doses that are run for longer time periods, a stringent PCT is not necessary.
  • High oral bio-availabilty without any damage to your liver; compared to the nasty toxic effects of steroids and prohormones on the liver.
  • Anabolic even at low doses
  • Good for strength
  • Great for lean mass gains

Liquid Sarms

ibutamoren

1


Ibutamoren MK-677
25mg/mL 30mL

ligandrol

2


Ligandrol LGD-4033
20mg/mL 30mL

ostarine

3


Ostarine MK-2866
50mg/mL 30mL

cardarine

4


Cardarine GW-501516
25mg/mL 30mL

RAD-140

5


RAD-140 30mg/mL 30mL

YK11

6


YK-11 10mg/mL 30mL

RAD-140

7


SR-9009 30mg/mL 30mL

Injections

injection testosteron

Testosterone Enanthate

Muscle gain Power increase Fat
burning
Side
effect
injection testosterone

Testosterone Propionate

Muscle gain Power increase Fat
burning
Side
effect
injection testosterone

Testosterone Cypionate

Muscle gain Power increase Fat
burning
Side
effect
sustanon 250

Sustanon 250

Muscle gain Power increase Fat
burning
Side
effect
injection deca

Deca Durabolin

Muscle gain Power increase Fat
burning
Side
effect
boldenone

Boldenone Undecylenate

Muscle gain Power increase Fat
burning
Side
effect
Trenbolone Enanthate

Trenbolone Enanthate

Muscle gain Power increase Fat
burning
Side
effect
Trenbolone Acetate

Trenbolone Acetate

Muscle gain Power increase Fat
burning
Side
effect
Primobolan

Primobolan

Muscle gain Power increase Fat
burning
Side
effect
Masteron

Masteron 100

Muscle gain Power increase Fat
burning
Side
effect
injection testosteron

Testosterone Enanthate

Muscle gain Power increase Fat
burning
Side
effect
injection testosterone

Testosterone Propionate

Muscle gain Power increase Fat
burning
Side
effect
sustanon 250

Sustanon 250

Muscle gain Power increase Fat
burning
Side
effect
injection deca

Deca Durabolin

Muscle gain Power increase Fat
burning
Side
effect
boldenone

Boldenone Undecylenate

Muscle gain Power increase Fat
burning
Side
effect
stanozolol

Stanozolol

Muscle gain Power increase Fat
burning
Side
effect
Trenbolone Enanthate

Trenbolone Enanthate

Muscle gain Power increase Fat
burning
Side
effect
Primobolan

Primobolan

Muscle gain Power increase Fat
burning
Side
effect
Masteron

Masteron

Muscle gain Power increase Fat
burning
Side
effect

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